This study, by Williamson et al,. utilized cortico-muscular and inter-muscular connectivity analyses to investigate the reorganization of motor control pathways after a stroke. The CST (corticospinal tract) is affected during strokes, leading to motor defects. Structural magnetic resonance imaging (MRI), specifically T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI) as those allowed for detailed assessments of lesions in the brain. T2WI is sensitive to water content changes and can identify pathological changes relating to CST. Quantitative analyses of lesions after stroke on MRIs can predict the degree of motor impairment. To localize the damaged pathways in the CST analysis, the white matter was examined using tractography to assess integrity. Lower fractional anisotropy (FA) values which quantify anisotropic diffusion levels of white matter, are associated with motor deficits. Additionally, resting-state fMRI was used to improve was used to improve accuracy of the approach, as tractography is highly sensitive to image quality, scanning parameters, and settings. Transcranial Magnetic Stimulation (TMS) was also used to investigate the excitability of the cortex, and was found to serve as an important tool to evaluate changes in the lesioned CST. CMC (corticomuscular connectivity) technique examined cortical neurons and their effect on muscle movements and motor unit output. CMC is measured by monitoring electroencephalography (EEG) signals to visualize real-time motor projections and sensory feedback. Inter-muscular coherence (IMC) is an analytical technique to observe the neural synchronization between muscles. CMC and IMC analyses provide a method to examine the motor control pathways after stroke and enhance the understanding of post-stroke impairments.