Bipolar disorder, especially the effects on the brain, have not been intensely studied and with the advancements of new technologies such as deformation-based morphometry (DBM) and voxel-based morphometry (VBM) these abnormalities can be distinguished between. These new methods have been used to detect changes in brain structures in two patient groups: 67 bipolar disorder patients and 70 healthy controls that do not have bipolar disorder or any neurological conditions. The scientists used magnetic resonance imaging scanning to acquire images and then used data processing of VBM and DBM models to analyze structural changes within the brain. The VBM and DBM models showed reduced grey matter volume in patients with bipolar disorder in multiple brain areas. There were also structural changes in the white matter areas that these statistical models were able to distinguish between, showing the white matter volume in bipolar disorder patients is also decreased. The findings of the study support that there are structural changes in individuals with bipolar disorder and that the VBM and DBM models are able to pick up these changes with around a 70% accuracy.