The article examines the connection between core genes and the immune microenvironment to better understand the mechanisms behind prostate cancer and propose new forms of treatment. The researchers used data from the GEO, TCGA, STRING databases and the Cytoscape software to identify differentially expressed genes, build a protein-protein interaction network, and select core modules. They investigated the correlations between immune cell infiltration and the expression level differences of core genes, which identified DKK3, SNAI2, WIF1, and FOXA1 as four potential core genes. It was found that in prostate cancer tissues, DKK3 and WIF1 were not only significantly downregulated, but also positively correlated with higher PSA, or prostate-specific antigen, which may indicate a higher risk for prostate cancer, and Gleason scores, which indicates a more aggressive prostate cancer. Furthermore, using the CTRP database, increased expression of DKK3 resulted in higher sensitivity to anti-tumor drugs, while increased expression of WIF1 reduced the efficacy of small molecule inhibitors. These findings point to the possibility of targeting the restoration of the tumor suppressor genes DKK3 and WIF1 in treating prostate cancer.