Comprehensive Summary
This review examines the accelerating role of artificial intelligence (AI) in ophthalmology, focusing on its use in the diagnosis, monitoring, and treatment of eye diseases. A comprehensive literature search of approximately 400 articles (from January 2016 to June 2020) was conducted using PubMed and Google Scholar, combining ophthalmology-related and machine learning-related keywords. The results indicate that AI systems, particularly those using convolutional neural networks (CNNs), achieve expert-level performance in classifying diabetic retinopathy (DR) and age-related macular degeneration (AMD) and interpreting optical coherence tomography (OCT) images. Commercial tools such as IDx-DR and EyRIS SELENA+ have received regulatory approval for screening for diabetic retinopathy. The review emphasizes the role of AI in enhancing the sustainability of the healthcare system, particularly with the aging world, the growth of low- and middle-income countries, and public health challenges, by streamlining screening, staging, and treatment planning while reducing the workload of experts.
Outcomes and Implications
This research is critically important because the ongoing aging of the population and the rising incidence of diabetes are causing a significant increase in conditions such as age-related macular degeneration and diabetic retinopathy, placing an increasing burden on already overstretched global healthcare systems. This situation is particularly critical in low- and middle-income countries, where trained specialists are scarce. AI-based systems could play a crucial role in implementing cost-effective universal screening and improving early treatment. The work is directly applicable to medicine by providing the potential for automated global screening of eye diseases, leading to earlier detection and referral, accelerating treatment by personalizing guidelines for individual patients, and improving patient adherence and compliance. The authors predict that the field of ophthalmology will be profoundly transformed by the global adoption of these technologies within the next two to five years, moving toward a future where AI systems enable significant improvements in patient management.