Neurotechnology

Creative experiences and brain clocks

Nature

Nature

Research Authors: Carlos Coronel-Oliveros, Joaquin Migeot, Fernando Lehue, Lucia Amoruso, Natalia Kowalczyk-Grębska, Natalia Jakubowska, Kanad N. Mandke, Joana Pereira Seabra, Patricio Orio, Dominic Campbell, Raul Gonzalez-Gomez, Pavel Prado, Jhosmary Cuadros, Enzo Tagliazucchi, Josephine Cruzat, Agustina Legaz, Vicente Medel, Hernan Hernandez, Sol Fittipaldi, Florencia Altschuler, Sebastian Moguilner, Sandra Baez, Hernando Santamaria-Garcia, Alfredis González-Hernández, Jasmin Bonilla-Santos, Bahar Güntekin, Claudio Babiloni, Daniel Abasolo, Gaetano Di Caterina, Görsev G. Yener, Javier Escudero, John Fredy Ochoa-Gómez, Marcio Soto-Añari, Martin A. Bruno, Pedro A. Valdes-Sosa, Renato Anghinah, Rodrigo A. Gonzalez-Montealegre, Ruaridh A. Clark, Adolfo M. García, Laura Kaltwasser, Martin Schürmann, Jil M. Meier, Aneta Brzezicka, Robert Whelan, Brian Lawlor, Ian H. Robertson, Christopher Bailey, Lucia Melloni, Nisha Sajnani & Agustin Ibanez

Research Authors: Carlos Coronel-Oliveros, Joaquin Migeot, Fernando Lehue, Lucia Amoruso, Natalia Kowalczyk-Grębska, Natalia Jakubowska, Kanad N. Mandke, Joana Pereira Seabra, Patricio Orio, Dominic Campbell, Raul Gonzalez-Gomez, Pavel Prado, Jhosmary Cuadros, Enzo Tagliazucchi, Josephine Cruzat, Agustina Legaz, Vicente Medel, Hernan Hernandez, Sol Fittipaldi, Florencia Altschuler, Sebastian Moguilner, Sandra Baez, Hernando Santamaria-Garcia, Alfredis González-Hernández, Jasmin Bonilla-Santos, Bahar Güntekin, Claudio Babiloni, Daniel Abasolo, Gaetano Di Caterina, Görsev G. Yener, Javier Escudero, John Fredy Ochoa-Gómez, Marcio Soto-Añari, Martin A. Bruno, Pedro A. Valdes-Sosa, Renato Anghinah, Rodrigo A. Gonzalez-Montealegre, Ruaridh A. Clark, Adolfo M. García, Laura Kaltwasser, Martin Schürmann, Jil M. Meier, Aneta Brzezicka, Robert Whelan, Brian Lawlor, Ian H. Robertson, Christopher Bailey, Lucia Melloni, Nisha Sajnani & Agustin Ibanez

AIIM Authors: Krish Mehta, Owen Anderson

AIIM Authors: Krish Mehta, Owen Anderson

Publication Date: Oct 3, 2025

Publication Date: Oct 3, 2025

Comprehensive Summary

This study presented by Coronel-Oliveros et al investigated the potential protective effects of diverse creative experiences on biological brain aging, quantified by the deviation between chronological age and predicted brain age. Researchers utilized machine learning (Support Vector Machines) and M/EEG functional connectivity data from 1,240 participants to build robust brain clock models, which were then used to compute brain age gaps (BAGs) in 232 individuals with different levels of creative expertise and short-term learning in domains such as tango dancers, musicians, visual artists, and video gamers. Delayed brain age (negative BAGs) was consistently observed across all creative domains, and this protective effect further scaled with the level of experience, demonstrating a greater impact in long-term expertise than in short-term learning. Detailed analysis revealed that lower BAGs were associated with plasticity-driven functional alterations, including increased local and global network efficiency, and modulations in biophysical coupling. The findings suggest a domain-independent link between creativity and brain health, providing evidence that creative experiences drive plasticity-related mechanisms that present an inverted pattern (reduced accelerated aging) compared to what is often seen in many neurological disorders.

Outcomes and Implications

This research is important because it provides direct evidence of specific, positive brain health benefits by linking diverse creative experiences to delayed biological aging, going beyond previous studies that focused primarily on cognitive or emotional effects. The finding that creative activities drive mechanisms like increased network efficiency and reduced accelerated aging is highly clinically relevant, especially since accelerated aging (larger positive BAGs) is typically observed in psychiatric/neurological conditions. The current results support the potential for creativity-based interventions to be used in preventive strategies and supportive therapies for both healthy populations and clinical settings.

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