Rose et al., “Blood Pressure Variability in Stroke: Building a Framework, Conceptualizing Intervention Opportunities, and Identifying Practical Research Objectives.” discusses the management of blood pressure variability (BPV) in stroke patients. Although drafted as a response to an earlier consensus statement addressed by the authors in response to a letter, the authors clarify that their aim was to create a framework for BPV management, conceptualize potential interventions, and outline the goals of practical research, rather than to issue clinical recommendations. They suggest that while such advanced indices as average real variability (ARV) and successive variation (SV) may, on a theoretical level, potentially improve BPV assessment, current bedside technology renders it impractical. Rather, they recommend simple measures such as systolic blood pressure (SBP) range until emerging tools enable immediate analytical analyses. The authors also note promising and fast antihypertensives including clevidipine, which provided fast, stable BP control in intracerebral hemorrhage (ICH) patients in the ACCELERATE trial and meets AHA/ASA recommendations for BP variability targeting. All of this leads the paper to conclude the need for prospective trials, such as the ongoing CLUTCH study, to validate not only BPV thresholds but also pharmacologic strategies prior to their implementation in clinical care.