Psychiatry

Comprehensive Summary

This study systematically reviews the use of natural language processing (NLP) to identify and predict psychosis in individuals at clinical high risk (CHR-P). Researchers gathered and analyzed studies from PubMed, Scopus, and Embase up to May 2025 that applied NLP techniques to speech data from CHR-P individuals, with the goal of determining diagnostic and prognostic accuracy. The final analysis included nine studies, covering 353 CHR-P individuals and 197 controls, using validated diagnostic criteria like the Structured Interview for Psychosis-Risk Syndromes/Scale of Prodromal Symptoms (SIPS/SOPS) and Comprehensive Assessment of At-Risk Mental States (CAARMS). These studies used various NLP models, such as Latent Semantic Analysis (LSA), Word2Vec, Sentence-BERT, and graph-based methods to analyze speech coherence, semantics, and syntax. Diagnostic accuracy ranged from 56% to 95% (AUC 0.86–0.99), and predictive accuracy for psychosis transition ranged from 83% to 100%. Despite promising accuracy levels, the review noted significant methodological diversity, small sample sizes, and limited generalizability, particularly due to reliance on English-trained NLP models and inconsistent validation techniques.

Outcomes and Implications

This research highlights the growing potential of speech-based NLP tools as early biomarkers for psychosis, which could revolutionize how mental health professionals screen for and monitor individuals at risk. By detecting subtle linguistic changes that precede clinical symptoms, NLP systems could enable earlier interventions, reduce the duration of untreated psychosis, and improve patient outcomes. However, the review stresses the need for larger, multilingual, and longitudinal studies to ensure reliability across diverse populations. For clinical adoption, ethical and governance frameworks must be strengthened to address biases, privacy concerns, and reproducibility. With further refinement and validation, NLP-based diagnostic models could become valuable, accessible tools in psychiatric assessments and preventive mental health care.

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© 2025 AIIM. Created by AIIM IT Team

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© 2025 AIIM. Created by AIIM IT Team

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© 2025 AIIM. Created by AIIM IT Team